Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block

Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P

J. Am. Chem. Soc. 2023. DOI: 10.1021/jacs.2c11107



Yellow polyketide pigment suppresses premature hatching in social amoeba

Günther M, Reimer C, Herbst R, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, Valiante V, Hillmann F, Stallforth P

Proc. Natl. Acad. Sci. 2022, e2116122119. DOI: 10.1073/pnas.2116122119

Tyrosine bioconjugation with hypervalent iodine

Declas N, Maynard JRJ, Menin L, Gasilova N, Götze S, Sprague JL, Stallforth P, Matile S, Waser J. Tyrosine bioconjugation with hypervalent iodine.

Chem. Sci. 2022. DOI: 10.1039/d2sc04558c

Graphical abstract: Tyrosine bioconjugation with hypervalent iodine

The potential of amoeba-based processes for natural product syntheses

Kufs JE, Reimer C, Stallforth P, Hillmann F, Regestein L

Curr. Opin. Biotechnol. 2022, e2022.102766. DOI: 10.1016/j.copbio.2022.102766

Functional Modulation of Chemical Mediators in Microbial Communities

Stallforth P, Hertweck C, Mittag M, Brakhage AA, Hellmich U

Trends. Biochem. Sci. 2022. DOI: 10.1016/j.tibs.2022.07.006

Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A

Bando Y, Hou Y, Seyfarth L, Probst J, Götze S, Bogacz M, Hellmich UA, Stallforth P, Mittag M, Arndt HD

Chem. Eur. J. 2022, e202104417. DOI: 10.1002/chem.202104417



Total synthesis and bioactivity mapping of geodiamolide H

Nasufović V, Küllmer F, Bößneck J, Dahse HM, Görls H, Bellstedt P, Stallforth P, Arndt HD

Chem. Eur. J. 2021, e202100989. DOI: 10.1002/chem.202100989

Lipopeptide-mediated bacterial interaction enables cooperative predator defense

Zhang S, Mukherji R,1, Chowdhury S , Reimer L, Stallforth P

Proc. Natl. Acad. Sci. USA 118, e2013759118. DOI: 10.1073/pnas.2013759118

The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity

Baunach M, Chowdhury S, Stallforth P, Dittmann E

Mol. Biol. Evol. DOI: 10.1093/molbev/msab015



Special Issue in Honor of Professor Jon Clardy

Seyedsayamdost M R, Stallforth P

J. Nat. Prod. 83565. DOI: 10.1021/acs.jnatprod.0c00199

Structure elucidation of bacterial nonribosomal lipopeptides

Götze S, Stallforth P

Org. Biomol. Chem. 18, 1710. DOI: 10.1039/C9OB02539A

Chimeric LuxR Transcription Factors Rewire Natural Product Regulation

Mukherji R, Zhang S, Chowdhury S, Stallforth P

Angew. Chem. Int. Ed. 59, 6192. DOI: 10.1101/584987



Biosynthesis of Pseudomonas‐Derived Butenolides

Klapper M, Schlabach K, Paschold A, Zhang S, Chowdhury S, Menzel K-D, Rosenbaum M A, Stallforth P

Angew. Chem. Int. Ed. 59, 5607.  DOI: 10.1002/anie.201914154

Structure Elucidation of the Syringafactin Lipopeptides Provides Insight in the Evolution of Nonribosomal Peptide Synthetases

Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, Garcia-Altares M, Willing K, Günther M, Stallforth P

Chem. Sci. 10, 10979. DOI: 10.1039/C9SC03633D

Disruption of membrane integrity by the bacteria-derived antifungal jagaricin.

Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S

Antimicrob. Agents Chemother. 63, 707.

Bioactivity and Mode of Action of Bacterial Tetramic Acids

Klapper M, Paschold A, Zhang S, Weigel C, Dahse H-M, Götze S, Pace S, König S, Rao Z, Reimer L, Werz O, Stallforth P

ACS Chem. Biol. 14, 1693.



The chemoattractant glorin is inactivated by ester cleavage during early multicellular development of Polysphondylium pallidum

Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T

ACS Chem. Biol. 13, 1506.

Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate

Broecker F, Götze S, Hudon J, Rathwell DCK, Pereira CL, Stallforth P, Chakkumkalag A, Seeberger PH

J. Med. Chem. 61, 4918.

Synergistic activity of co-secreted natural products from amoebae-associated bacteria

Arp J, Götze S, Mukherji R, Mattern D, Garcia-Altares M, Klapper M, Brock D, Brakhage AA, Strassmann J, Queller D, Bardl B, Willing K, Peschel G, Stallforth P

Proc. Natl. Acad. Sci. USA 115, 3758.

Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase

Klapper M, Braga D, Lackner G, Herbst R, Stallforth P

Cell Chem. Biol. 25, 659.

The Role of Bacterial Natural Products in Predator Defense

Klapper M, Arp J, Günther M, Stallforth P

Synlett, 29, 537.

Natural Products from Social Amoebae

Barnett R, Stallforth P

Chem. Eur. J, 24, 4202.



Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin

Götze S, Herbst-Irmer R, Klapper M, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, Stallforth P

ACS Chem. Biol. 12, 2498.

Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine

Gallegos-Monterrosa R, Kankel S, Götze S, Barnett R, Stallforth P, Kovács AT

J. Bacteriol. 199:e00204-17.

Rationalizing the Right Ratios

Arp J, Stallforth P

Cell Chem. Biol. 24, 539.

A Versatile Synthesis of the Signaling Peptide Glorin

Barnett R, Raszkowski D, Winckler T, Stallforth P

Beilstein J. Org. Chem. 13, 247.



Bacterial alkaloids prevent amoebal predation

Klapper M, Götze S, Barnett R, Willing K, Stallforth P

Angew. Chem. Int. Ed. 55, 8944



Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus

Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D

Chem. Biol. 22, 1325.

Total Synthesis of Legionaminic Acid as Basis for Serological Studies

Matthies S, Stallforth P, Seeberger PH

J. Am. Chem. Soc. 137, 2848.



A semi-synthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice

Cavallari M, Stallforth P, Kalinichenko A, Rathwell DCK, Gronewold TMA, Adibekian A, Mori L, Landmann R, Seeberger PH, DeLibero G

Nat. Chem. Biol. 10, 950.

Atlas for drug discovery

Stallforth P, Clardy J

Proc. Natl. Acad. Sci. USA 111, 3655.

A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene

Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J

Proc. Natl. Acad. Sci. USA 110, 14528.

X-ray crystallography: One size fits most

Stallforth P, Clardy J

Nature 495, 456.



Protein evolution: when two become three

Stallforth P, Clardy J

Curr. Biol. 22, R685.

De novo chemoenzymatic synthesis of sialic acid

Stallforth P, Matthies S, Adibekian A, Gillingham DG, Hilvert D, Seeberger PH

Chem. Commun. 48, 11987.



Recent advances in carbohydrate-based vaccines

Hecht ML, Stallforth P, Silva DV, Adibekian A, Seeberger PH

Curr. Opin. Chem. Biol. 13, 354.

2009 Claude S. Hudson Award in Carbohydrate Chemistry. Carbohydrates: a frontier in medicinal chemistry

Stallforth P, Lepenies B, Adibekian A, Seeberger PH

J. Med. Chem. 52, 5561.