2026
Microbial DL-Peptidases Enable Predator Defense and Facilitate Structure Elucidation of Complex Natural Products
Zhang S, Huang Y, Schlabach K, Tran MA, Nachawati R, Bader N, Komor AJ, Hertweck C, Schindelin H, Lakemeyer M, Hellmich UA, Stallforth P
J. Am. Chem. Soc. 2026. DOI: 10.1021/jacs.5c17955
2025
Actifensin Evolution in the Human Oral Cavity over the Past 100,000 Years
Herbst R, Ibrahim A, Hübner A, Knüpfer U, Regestein L, Wiedemann C, Hellmich UA, Warinner C, Stallforth P
J. Am. Chem. Soc. 2025, 147, 52. DOI: 10.1021/jacs.5c14335
Global profiling of polyketide synthases in facultative multicellular eukaryotes
Günther M, Herbst R, Ueberschaar N, Hildebrandt D, Reimer L, Stallforth P
Proc. Natl. Acad. Sci. U.S.A. 2025, 122, 45. DOI: 10.1073/pnas.2515852122
Semiautomated Total Synthesis of the Cyclic Lipodepsipeptide Anikasin
Bando Y, Klapper M, Herbst R, Sachse A, Stallforth P, Arndt HD
Org. Lett. 2025, 27, 11. DOI: 10.1021/acs.orglett.5c00111
Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation
Zhang S, Ying H, Nachawati R, Huber P, Walther G, Gregor L, Vilotijević I, Stallforth P
Angew. Chem. Int. Ed. 2025, 64, 25. DOI: 10.1002/anie.202503679
A chemical radar allows bacteria to detect and kill predators
Zhang S, Schlabach K, Pérez Carrillo VH, Ibrahim A, Nayem S, Komor A, Mukherji R, Chowdhury S, Reimer L, Trottmann F, Vlot AC, Hertweck C, Hellmich UA, Stallforth P
Cell 2025, 188, 9. DOI: 10.1016/j.cell.2025.02.033
Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro
Li K, Cho YI, Tran MA, Wiedemann C, Zhang S, Koweek RS, Hoàng NK, Hamrick GS, Bowen MA, Kokona B, Stallforth P, Beld J, Hellmich UA, Charkoudian LK
ACS Chem. Biol. 2025, 20. DOI: 10.1021/acschembio.4c00678
2024
Metamorphosis of a unicellular green alga in the presence of acetate and a spatially structured three-dimensional environment
Vuong T, Shetty P, Kurtoglu E, Schultz C, Schrader L, Then P, Petersen J, Westermann M, Rredhi A, Chowdhury S, Mukherji R, Schmitt M, Popp J, Stallforth P, Mittag M
New Phytol. 2024, 245, 3. DOI: 10.1111/nph.20299
MIBiG 4.0: Advancing biosynthetic gene cluster curation through global collaboration
Zdouc M, Blin K, Louwen N, …, Klapper M, …, Weber T, Medema MH
Nucleic Acids Res. 2024. DOI: 10.1093/nar/gkae1115
Accessing microbial natural products of the past
Klapper M, Stallforth P
microLife 2024, 5. DOI: 10.1093/femsml/uqae
Naturstoffe aus der Vergangenheit
Klapper M, Ramm M, Stallforth P
BIOspektrum 2024, 30. DOI: 10.1007/s12268-024-2339-y
2023
Nonribosomal peptides protect Pseudomonas nunensis 4A2e from amoebal and nematodal predation
Pflanze S, Mukherji R, Ibrahim A, Günther M, Götze S, Chowdhury S, Reimer L, Regestein L, Stallforth P
Chem. Sci. 2023, 14. DOI: 10.1039/D3SC03335J
Bifurcate evolution of quinone synthetases in basidiomycetes
Seibold PS, Lawrinowitz S, Raztsou I, Gressler M, Arndt H-D, Stallforth P, Hoffmeister D
Fungal Biol. Biotechnol. 2023, 10, 14. DOI: 10.1186/s40694-023-00162-1
Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic
Klapper M, Hübner A, Ibrahim A, Wasmuth I, Borry M, Haensch VG, Zhang S, Al-Jammal WK, Suma H, Fellows Yates JA, Frangenberg J, Velsko IM, Chowdhury S, Herbst R, Bratovanov EV, Dahse H-M, Horch T, Hertweck C, González Morales MR, Straus LG, Vilotijevic I, Warinner C, Stallforth P
Science 2023, 380, 619. DOI: 10.1126/science.adf5300
Image credit: Werner Siemens Foundation, Felix Wey
Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block
Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P
J. Am. Chem. Soc. 2023, 145, 4. DOI: 10.1021/jacs.2c11107
Functional Modulation of Chemical Mediators in Microbial Communities
Stallforth P, Hertweck C, Mittag M, Brakhage AA, Hellmich U
Trends Biochem. Sci. 2023, 48, 1. DOI: 10.1016/j.tibs.2022.07.006
2022
Yellow polyketide pigment suppresses premature hatching in social amoeba
Günther M, Reimer C, Herbst R, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, Valiante V, Hillmann F, Stallforth P
Proc. Natl. Acad. Sci. U.S.A. 2022, 119, 43. DOI: 10.1073/pnas.2116122119
Tyrosine bioconjugation with hypervalent iodine
Declas N, Maynard JRJ, Menin L, Gasilova N, Götze S, Sprague JL, Stallforth P, Matile S, Waser J. Tyrosine bioconjugation with hypervalent iodine.
Chem. Sci. 2022, 13, 43. DOI: 10.1039/d2sc04558c
The potential of amoeba-based processes for natural product syntheses
Kufs JE, Reimer C, Stallforth P, Hillmann F, Regestein L
Curr. Opin. Biotechnol. 2022, 77. DOI: 10.1016/j.copbio.2022.102766
Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A
Bando Y, Hou Y, Seyfarth L, Probst J, Götze S, Bogacz M, Hellmich UA, Stallforth P, Mittag M, Arndt HD
Chem. Eur. J. 2022, 28, 20. DOI: 10.1002/chem.202104417
2021
Total synthesis and bioactivity mapping of geodiamolide H
Nasufović V, Küllmer F, Bößneck J, Dahse HM, Görls H, Bellstedt P, Stallforth P, Arndt HD
Chem. Eur. J. 2021, 27, 45. DOI: 10.1002/chem.202100989
Lipopeptide-mediated bacterial interaction enables cooperative predator defense
Zhang S, Mukherji R,1, Chowdhury S , Reimer L, Stallforth P
Proc. Natl. Acad. Sci. U.S.A. 2021, 118, 6. DOI: 10.1073/pnas.2013759118
The Landscape of Recombination Events That Create Nonribosomal Peptide Diversity
Baunach M, Chowdhury S, Stallforth P, Dittmann E
Mol. Biol. Evol. 2021, 38, 5. DOI: 10.1093/molbev/msab015
2020
Special Issue in Honor of Professor Jon Clardy
Seyedsayamdost M R, Stallforth P
J. Nat. Prod. 2020, 83, 3. DOI: 10.1021/acs.jnatprod.0c00199
Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
Mukherji R, Zhang S, Chowdhury S, Stallforth P
Angew. Chem. Int. Ed. 2020, 132, 15. DOI: 10.1002/ange.201914449
2019
Biosynthesis of Pseudomonas‐Derived Butenolides
Klapper M, Schlabach K, Paschold A, Zhang S, Chowdhury S, Menzel K-D, Rosenbaum M A, Stallforth P
Angew. Chem. Int. Ed. 2019, 59, 14. DOI: 10.1002/anie.201914154
Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases
Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, Garcia-Altares M, Willing K, Günther M, Stallforth P
Chem. Sci. 2019, 10. DOI: 10.1039/C9SC03633D
Disruption of membrane integrity by the bacteria-derived antifungal jagaricin
Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S
Antimicrob. Agents Chemother 2019, 63, 9. DOI: 10.1128/AAC.00707-19
Bioactivity and Mode of Action of Bacterial Tetramic Acids
Klapper M, Paschold A, Zhang S, Weigel C, Dahse H-M, Götze S, Pace S, König S, Rao Z, Reimer L, Werz O, Stallforth P
ACS Chem. Biol. 2019, 14, 8. DOI: 10.1021/acschembio.9b00388
Solid-Phase-Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product Aurantizolicin
Oberheide A, Pflanze S, Stallforth P, Arndt H-D
Org. Lett. 2019, 21, 3. DOI: 10.1021/acs.orglett.8b03940
2018
The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum
Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T
ACS Chem. Biol. 2018, 13, 6. DOI: 10.1021/acschembio.8b00046
Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate
Broecker F, Götze S, Hudon J, Rathwell DCK, Pereira CL, Stallforth P, Chakkumkalag A, Seeberger PH
J. Med. Chem. 2018, 61, 11. DOI: 10.1021/acs.jmedchem.8b00312
Synergistic activity of co-secreted natural products from amoebae-associated bacteria
Arp J, Götze S, Mukherji R, Mattern D, Garcia-Altares M, Klapper M, Brock D, Brakhage AA, Strassmann J, Queller D, Bardl B, Willing K, Peschel G, Stallforth P
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 15. DOI: 10.1073/pnas.17217901
Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase
Klapper M, Braga D, Lackner G, Herbst R, Stallforth P
Cell Chem. Biol. 2018, 25, 6. DOI: 10.1016/j.chembiol.2018.02.013
2017
Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
Götze S, Herbst-Irmer R, Klapper M, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, Stallforth P
ACS Chem. Biol. 2017, 12, 10. DOI: 10.1021/acschembio.7b00589
Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine
Gallegos-Monterrosa R, Kankel S, Götze S, Barnett R, Stallforth P, Kovács AT
J. Bacteriol. 2017, 199, 22. DOI: 10.1128/jb.00204-17
Versatile synthesis of the signaling peptide glorin
Barnett R, Raszkowski D, Winckler T, Stallforth P
Beilstein J. Org. Chem. 2017, 13. DOI: 10.3762/bjoc.13.27
![[1860-5397-13-27-1]](https://www.beilstein-journals.org/bjoc/content/figures/1860-5397-13-27-1.svg?max-width=637&background=FFFFFF)
2016
Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13–15, Geneva, Switzerland
Adibekian A, Stallforth P
ACS Chem. Biol. 2016, 11, 4. DOI: 10.1021/acschembio.6b00267
Bacterial Alkaloids Prevent Amoebal Predation
Klapper M, Götze S, Barnett R, Willing K, Stallforth P
Angew. Chem. Int. Ed. 2016, 55, 31. DOI: 10.1002/anie.201603312
2015
Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus
Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D
Chem. Biol. 2015, 22, 10. DOI: 10.1016/j.chembiol.2015.08.016
2014
A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice
Cavallari M, Stallforth P, Kalinichenko A, Rathwell DCK, Gronewold TMA, Adibekian A, Mori L, Landmann R, Seeberger PH, DeLibero G
Nat. Chem. Biol. 2014, 10. DOI: 10.1038/nchembio.1650
Atlas for drug discovery
Stallforth P, Clardy J
Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 10. DOI: 10.1073/pnas.140051611
A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene
Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J
Proc. Natl. Acad. Sci. U.S.A. 2014, 110, 36. DOI: 10.1073/pnas.1308199110
X-ray crystallography: One size fits most
Stallforth P, Clardy J
Nature 2014, 495. DOI: 10.1038/495456a
2012
De novo chemoenzymatic synthesis of sialic acid
Stallforth P, Matthies S, Adibekian A, Gillingham DG, Hilvert D, Seeberger PH
Chem. Commun. 2012, 48, 98. DOI: 10.1039/C2CC37305J
2011
Comparative bioinformatics analysis of the mammalian and bacterial glycomes
Adibekian A, Stallforth P, Hecht ML, Werz DB, Gagneux P, Seeberger PH
Chem. Sci. 2011, 2. DOI: 10.1039/C0SC00322K
2010
Chemoenzymatic synthesis of differentially protected 3-deoxysugars
Gillingham DG, Stallforth P, Adibekian A, Seeberger PH, Hilvert D
Nat. Chem. 2010, 2. DOI: 10.1038/nchem.504
Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block
Ohara T, Adibekian A, Esposito D, Stallforth P, Seeberger PH
Chem Commun. 2010, 46, 23. DOI: 10.1039/C000784F
2009
Recent advances in carbohydrate-based vaccines
Hecht ML, Stallforth P, Silva DV, Adibekian A, Seeberger PH
Curr. Opin. Chem. Biol. 2009, 13, 3. DOI: 10.1016/j.cbpa.2009.05.127
2009 Claude S. Hudson Award in Carbohydrate Chemistry. Carbohydrates: a frontier in medicinal chemistry
Stallforth P, Lepenies B, Adibekian A, Seeberger PH
J. Med. Chem. 2009, 52, 18. DOI: 10.1021/jm900819p
