2023
Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block
Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P
J. Am. Chem. Soc. 2023. DOI: 10.1021/jacs.2c11107
2022
Yellow polyketide pigment suppresses premature hatching in social amoeba
Günther M, Reimer C, Herbst R, Kufs JE, Rautschek J, Ueberschaar N, Zhang S, Peschel G, Reimer L, Regestein L, Valiante V, Hillmann F, Stallforth P
Proc. Natl. Acad. Sci. 2022, e2116122119. DOI: 10.1073/pnas.2116122119
Tyrosine bioconjugation with hypervalent iodine
Declas N, Maynard JRJ, Menin L, Gasilova N, Götze S, Sprague JL, Stallforth P, Matile S, Waser J. Tyrosine bioconjugation with hypervalent iodine.
Chem. Sci. 2022. DOI: 10.1039/d2sc04558c
The potential of amoeba-based processes for natural product syntheses
Kufs JE, Reimer C, Stallforth P, Hillmann F, Regestein L
Curr. Opin. Biotechnol. 2022, e2022.102766. DOI: 10.1016/j.copbio.2022.102766
Functional Modulation of Chemical Mediators in Microbial Communities
Stallforth P, Hertweck C, Mittag M, Brakhage AA, Hellmich U
Trends. Biochem. Sci. 2022. DOI: 10.1016/j.tibs.2022.07.006
Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A
Bando Y, Hou Y, Seyfarth L, Probst J, Götze S, Bogacz M, Hellmich UA, Stallforth P, Mittag M, Arndt HD
Chem. Eur. J. 2022, e202104417. DOI: 10.1002/chem.202104417
2021
Total synthesis and bioactivity mapping of geodiamolide H
Nasufović V, Küllmer F, Bößneck J, Dahse HM, Görls H, Bellstedt P, Stallforth P, Arndt HD
Chem. Eur. J. 2021, e202100989. DOI: 10.1002/chem.202100989
Lipopeptide-mediated bacterial interaction enables cooperative predator defense
Zhang S, Mukherji R,1, Chowdhury S , Reimer L, Stallforth P
Proc. Natl. Acad. Sci. USA 118, e2013759118. DOI: 10.1073/pnas.2013759118
2020
Special Issue in Honor of Professor Jon Clardy
Seyedsayamdost M R, Stallforth P
J. Nat. Prod. 83, 565. DOI: 10.1021/acs.jnatprod.0c00199
2019
Biosynthesis of Pseudomonas‐Derived Butenolides
Klapper M, Schlabach K, Paschold A, Zhang S, Chowdhury S, Menzel K-D, Rosenbaum M A, Stallforth P
Angew. Chem. Int. Ed. 59, 5607. DOI: 10.1002/anie.201914154
Structure Elucidation of the Syringafactin Lipopeptides Provides Insight in the Evolution of Nonribosomal Peptide Synthetases
Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, Garcia-Altares M, Willing K, Günther M, Stallforth P
Chem. Sci. 10, 10979. DOI: 10.1039/C9SC03633D
Disruption of membrane integrity by the bacteria-derived antifungal jagaricin.
Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S
Antimicrob. Agents Chemother. 63, 707.
Bioactivity and Mode of Action of Bacterial Tetramic Acids
Klapper M, Paschold A, Zhang S, Weigel C, Dahse H-M, Götze S, Pace S, König S, Rao Z, Reimer L, Werz O, Stallforth P
ACS Chem. Biol. 14, 1693.
Solid-Phase-Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product Aurantizolicin
Oberheide A, Pflanze S, Stallforth P, Arndt H-D
Org. Lett. 21, 729.
2018
The chemoattractant glorin is inactivated by ester cleavage during early multicellular development of Polysphondylium pallidum
Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T
ACS Chem. Biol. 13, 1506.
Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate
Broecker F, Götze S, Hudon J, Rathwell DCK, Pereira CL, Stallforth P, Chakkumkalag A, Seeberger PH
J. Med. Chem. 61, 4918.
Synergistic activity of co-secreted natural products from amoebae-associated bacteria
Arp J, Götze S, Mukherji R, Mattern D, Garcia-Altares M, Klapper M, Brock D, Brakhage AA, Strassmann J, Queller D, Bardl B, Willing K, Peschel G, Stallforth P
Proc. Natl. Acad. Sci. USA 115, 3758.
Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase
Klapper M, Braga D, Lackner G, Herbst R, Stallforth P
Cell Chem. Biol. 25, 659.
The Role of Bacterial Natural Products in Predator Defense
Klapper M, Arp J, Günther M, Stallforth P
Synlett, 29, 537.
Natural Products from Social Amoebae
Barnett R, Stallforth P
Chem. Eur. J, 24, 4202.
2017
Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
Götze S, Herbst-Irmer R, Klapper M, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, Stallforth P
ACS Chem. Biol. 12, 2498.
Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine
Gallegos-Monterrosa R, Kankel S, Götze S, Barnett R, Stallforth P, Kovács AT
J. Bacteriol. 199:e00204-17.
Rationalizing the Right Ratios
Arp J, Stallforth P
Cell Chem. Biol. 24, 539.
A Versatile Synthesis of the Signaling Peptide Glorin
Barnett R, Raszkowski D, Winckler T, Stallforth P
Beilstein J. Org. Chem. 13, 247.
2016
Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland
Adibekian A, Stallforth P
ACS Chem. Biol. 11, 816.
Bacterial alkaloids prevent amoebal predation
Klapper M, Götze S, Barnett R, Willing K, Stallforth P
Angew. Chem. Int. Ed. 55, 8944
2015
Three Redundant Synthetases Secure Redox-Active Pigment Production in the Basidiomycete Paxillus involutus
Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D
Chem. Biol. 22, 1325.
Total Synthesis of Legionaminic Acid as Basis for Serological Studies
Matthies S, Stallforth P, Seeberger PH
J. Am. Chem. Soc. 137, 2848.
2014
A semi-synthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice
Cavallari M, Stallforth P, Kalinichenko A, Rathwell DCK, Gronewold TMA, Adibekian A, Mori L, Landmann R, Seeberger PH, DeLibero G
Nat. Chem. Biol. 10, 950.
Atlas for drug discovery
Stallforth P, Clardy J
Proc. Natl. Acad. Sci. USA 111, 3655.
A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene
Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J
Proc. Natl. Acad. Sci. USA 110, 14528.
X-ray crystallography: One size fits most
Stallforth P, Clardy J
Nature 495, 456.
2012
Protein evolution: when two become three
Stallforth P, Clardy J
Curr. Biol. 22, R685.
De novo chemoenzymatic synthesis of sialic acid
Stallforth P, Matthies S, Adibekian A, Gillingham DG, Hilvert D, Seeberger PH
Chem. Commun. 48, 11987.
2010
Chemoenzymatic synthesis of differentially protected 3-deoxysugars
Gillingham DG, Stallforth P, Adibekian A, Seeberger PH, Hilvert D
Nat. Chem. 2, 102.
Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block
Ohara T, Adibekian A, Esposito D, Stallforth P, Seeberger PH
Chem Commun. 46, 4106.
De novo synthesis of a 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block for the preparation of a Bacteroides fragilis A1 polysaccharide fragment
Pragani R, Stallforth P, Seeberger PH
Org. Lett. 12, 1624.
2009
Recent advances in carbohydrate-based vaccines
Hecht ML, Stallforth P, Silva DV, Adibekian A, Seeberger PH
Curr. Opin. Chem. Biol. 13, 354.
2009 Claude S. Hudson Award in Carbohydrate Chemistry. Carbohydrates: a frontier in medicinal chemistry
Stallforth P, Lepenies B, Adibekian A, Seeberger PH
J. Med. Chem. 52, 5561.
2008
De novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae
Stallforth P, Adibekian A, Seeberger PH
Org. Lett. 10, 1573.
