We congratulate all authors of our latest paper, which is published under the title “Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation” in Angewandte Chemie International Edition!
Pseudomonas syringae, a soil-dwelling pathogen, produces structurally diverse natural products shaped by ecological interactions with amoebae and fungi. Pangenomic analysis of 18 strains uncovered 231 biosynthetic gene clusters, including those responsible for two novel compound classes—syrilipamides and chlorosecimides—with amoebicidal and antifungal activities. The identification of SecA, a halogenase essential for secimide chlorination, highlights the ecological significance and biotechnological potential of these metabolites.
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